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This compendium is a collection of technical information and applications performed on the Agilent 1220 Infinity LC and its predecessor the Agilent 1120 Compact LC. Based on well-established Agilent LC technologies, the 1120 Compact LC featured simplified functions and easy-to-use software to facilitate conventional HPLC up to 400 bar. The 1120 Compact LC was mainly deployed in small to medium sized quality control or research laboratories. A customer survey conducted by Agilent revealed the requirements for more instrument flexibility and a wider power range. In response Agilent introduced the 1220 Infinity LC, leveraging the latest technology by sharing components with the Agilent 1260 Infinity LC while maintaining excellent value and compatibility.